Elizabeth Kyran on Muck Rack

Elizabeth Kyran

As seen in: BioRxiv
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Articles

Demethylating agents drive PARP inhibitor resistance in ovarian carcinomas with BRCA1 gene silencing

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By Ksenija Nesic, Franziska Geissler, Lijun Xu, Elizabeth Kyran
| BioRxiv
Abstract DNA methyltransferase 1 inhibitor (DNMT1i) therapy is a promising option for increasing immune response as part of combination cancer therapy. High–grade serous ovarian carcinoma (HGSOC) is a highly aggressive cancer with poor survival outcomes, where DNMT1i therapy is being increasingly explored. HGSOC with epigenetically silenced BRCA1 has been shown to respond to PARP inhibitor (PARPi) treatment – a core targeted therapy for HGSOC.
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