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Elkordy Alaa on Muck Rack

Elkordy Alaa

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Articles

Stress-induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells

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By Kuniyasu Niizuma, Teiji Tominaga, Takaaki Abe, Elkordy Alaa, Eikan Mishima, Yasutoshi Akiyama, Miki Fujimura
| Color Research & Application Verified
Transfer RNA (tRNA) plays a role in stress response programs involved in various pathological conditions including neurological diseases. Under cell stress conditions, intracellular tRNA is cleaved by a specific ribonuclease, angiogenin, generating tRNA-derived fragments or tRNA-derived stress-induced RNA (tiRNA). Generated tiRNA contributes to the cell stress response and has potential cell protective effects.
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