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Ellen Leich-Zbat on Muck Rack

Ellen Leich-Zbat

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Articles

VS-4718 enhances apoptosis induced by low-dose carfilzomib and overcomes carfilzomib resistance in PSMB5 -mutated proteasome inhibitor resistant multiple myeloma

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By Sofia Catalina Heredia-Guerrero, Marietheres Evers, Thorsten Stühmer, Ralf Bargou, Andreas Rosenwald, Manik Chatterjee, Daniela Brünnert, Ellen Leich-Zbat, Tina Grieb, Hilka Rauert-Wunderlich
| Nature Verified
Abstract The introduction of proteasome inhibitors (PIs) into multiple myeloma (MM) treatment has substantially improved therapeutic options and survival rates. However, the development of resistance to PIs as well as serious side effects of PI treatment continue to justify the search for effective, less burdensome combination therapies.
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