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Ellie Bare on Muck Rack

Ellie Bare

As seen in: Nature, eLife
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Articles

Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

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By Arpa Hudait, Ryan Burdick, Ellie Bare
| eLife
eLife Assessment This study investigates how the HIV inhibitor lenacapavir influences capsid mechanics and interactions with the nuclear pore complex. It provides important insights into how drug-induced hyperstabilization of the viral shell can compromise its structural integrity during nuclear entry. The modeling is technically sophisticated, and the analyses provide convincing support for the mechanistic conclusions.
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HIV-1 uncoating location dictates sites of integration

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By Ryan Burdick, Sean C. Patro, Krista A. Delviks-Frankenberry, Olga A. Nikolaitchik, Stephen Hughes, Xiaolin Wu, Wei-Shau Hu, Vinay Pathak, Ellie Bare, Rokeya Siddiqui
| Nature Verified
Abstract HIV-1 cores enter the nucleus and undergo capsid disassembly (uncoating) near their integration site. Although most viral cores are localized to nuclear speckles (NSs), the spatial relationship between the uncoating site and integration site remains unclear.
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