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Constitutive Endolysosomal Perforation in Neurons allows Induction of alpha-Synuclein Aggregation by Internalized Pre-Formed Fibrils

Jan 01, 2024 |

By Anwesha Sanyal, Gustavo Scanavachi, Elliott Somerville, Anand Saminathan

| biorxiv.org

Abstract The endocytic pathway is both an essential route of molecular uptake in cells and a potential entry point for pathology-inducing cargo. The cell-to-cell spread of cytotoxic aggregates, such as those of alpha-synuclein (alpha-syn) in Parkinson s Disease (PD), exemplifies this duality.

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Elliott Somerville

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Elliott Somerville’s Biography

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Constitutive Endolysosomal Perforation in Neurons allows Induction of alpha-Synuclein Aggregation by Internalized Pre-Formed Fibrils

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