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Elnaz Banijamali on Muck Rack

Elnaz Banijamali

As seen in: BioRxiv
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Articles

Biophysics of microRNA-34a targeting and its influence on down-regulation

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By Lara Sweetapple, Walter Becker, David Kosek, Elnaz Banijamali
| BioRxiv
Abstract microRNAs (miRNAs) regulate target mRNA expression post-transcriptionally through their association with Argonaute 2 (AGO2) proteins. Predicting the efficiency of mRNA repression by miRNA has been limited by our comprehension of the structure-function relationship within miRNA binding sites. Using a combination of EMSA, luciferase reporter assays, and structural probing, we investigated the interaction between the human tumour suppressor miR-34a and 12 mRNA targets.
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