Elory Leonard on Muck Rack

Elory Leonard

As seen in: Wiley Online Library
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Articles

Addition of hydroxyurea (hydroxycarbamide) enhances the efficacy of fludarabine/cytarabine‐based salvage regimens against acute myeloid leukaemia

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By Ingrid Lilienthal, Christer Nilsson, Elory Leonard, Sijia Tao
| Wiley Online Library Verified
INTRODUCTION Over half of patients with de novo acute myeloid leukaemia (AML) treated with curative intent will relapse or be refractory to treatment.1, 2 The prognosis of relapsed/refractory AML (RR-AML) is dismal, with a 5-year overall survival (OS) of around 10%.3 A prerequisite for long-term survival is allogeneic haematopoietic stem cell transplantation (allo-HSCT), generally after a second complete remission following salvage therapy.4, 5 While less intensive regimens based on...
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Skin mesenchymal niches maintain and protect AML-initiating stem cells

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By Lakshmi Sandhow, Huan Cai, Elory Leonard, Pingnan Xiao
| rupress.org
Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model. These AML cells could regenerate AML after transplantation.
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Skin mesenchymal niches maintain and protect AML-initiating stem cells

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By Lakshmi Sandhow, Huan Cai, Elory Leonard, Pingnan Xiao
| biorxiv.org
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