Eman AE El-Helw on Muck Rack

Eman AE El-Helw

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Synthesis and antimicrobial activity of thiophene-based heterocycles derived from thiophene-2-carbohydrazide

|
By Sayed K. Ramadan, Eman AE El-Helw, Abdullah YA Alzahrani
| future-science.com
Aim: Thiophene-based heterocycles were synthesized and evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus, Escherichia coli, Clostridium difficile and Candida albicans strains. Methods: Antimicrobial activity was determined using the broth microdilution method. Results: Spiro-indoline-oxadiazole 17 displayed the highest activity against C. difficile while having no effects against other bacterial strains.
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