Elizabeth Maupin

Abstract Demyelinating diseases, including multiple sclerosis (MS), are characterized by loss of myelin and progressive neurodegeneration. It remains unclear if demyelination mouse models, such as cuprizone (CPZ) and lysophosphatidylcholine (LPC) elicit distinct responses or are comparable to human disease. Here, we integrate new and published single-cell transcriptomic datasets from CPZ- and LPC-induced demyelination and compare them with human MS data.

8-OhdG 8-Hydroxy-2′-deoxyguanosine BCL2 B-cell leukemia/lymphoma 2 CCL C-C motif chemokine ligand CD4 cluster of differentiation 4 CDK cyclin-dependent kinase CDKN cyclin-dependent kinase inhibitor CNS central nervous system CS cellular senescence CXCL C-X-C motif chemokine ligand DAM disease associated microglia EAE experimental autoimmune/allergic encephalomyelitis GFAP glial fibrillary acidic protein HMGB1 high mobility group box 1 IKK IκB kinase Il interleukin JAK/STAT Janus kinase/signal...

Julie Gunnigle is the only candidate that has promised to never criminalize reproductive health choices The Maricopa County Attorney’s Office is frequently reported for misconduct, resulting in a recent surge of many of its prosecutors leaving. I’ve been an attorney in the Valley for 11 years. Before entering private practice, I was a prosecutor for Glendale and Gila County.