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Emerson Wayland Sullivan

As seen in: PLOS, BioRxiv
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Articles

Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases

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By Max Ticó, Universitat de Barcelona, Emerson Wayland Sullivan, Roderic Guigó
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Ticó M, Sullivan E, Guigó R, Mariotti M (2026) Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases. PLoS Comput Biol 22(1): e1013885.
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Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases

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By Max Ticó, Emerson Wayland Sullivan, Roderic Guigó, Marco Mariotti
| BioRxiv
Abstract Selenocysteine (Sec) is a non-canonical amino acid incorporated into selenoproteins, oxidoreductase enzymes carrying essential roles in redox homeostasis. Sec insertion is performed in response to the UGA codon, normally interpreted as a stop codon, but recoded in selenoprotein mRNAs. Owing to the dual function of UGA, the identification of selenoprotein genes poses a challenge. We show here that the vertebrate selenoprotein genes are widely misannotated in the major public databases.
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