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Emil-August Torp

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Articles

Combining genome-wide polygenic scores with registry data for colorectal cancer risk-based screening

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By Anne Krogh Nøhr, Rikke Hedegaard Jensen, Laurids Østergaard Poulsen, Ole Thorlacius-Ussing, Simon Rasmussen, Berit Andersen, Ismail Gögenur, Erik S. Sørensen, Christian Erikstrup, Nanna Brøns, Michael C Schwinn, Christina Mikkelsen, Mie Topholm Bruun, Malene Møller Jørgensen, Claus Anders Bertelsen, Jens Hillingsø, Estrid Høgdall, Martin Bøgsted, Rasmus Froberg Brøndum, Marie Giehm Overby, Mads Munk Nielsen, Emil-August Torp
| Nature Verified
Abstract Polygenic risk scores (PRS) show potential for risk-based colorectal cancer (CRC) screening, but their utility must be assessed across diverse ancestries and tumour characteristics and compared with the current standard, the faecal immunochemical test (FIT). The cohort included 112,204 individuals from the Copenhagen Hospital Biobank (8995 with adenoma and 9246 with CRC), all with linked genetic and health registry data. A subset (N = 20,658) also had FIT results.
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