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Émile Barbé

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Clustering the protein universe of life using DIAMOND DeepClust

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By Benjamin Buchfink, Haim Ashkenazy, Klaus Reuter, John Kennedy, Hajk-Georg Drost, Émile Barbé
| Nature Verified
Abstract Relating billions of proteins across the tree of life remains a challenging task for comparative biosphere genomics and artificial intelligence-driven structure prediction. Here we present DIAMOND DeepClust, a cascaded, ultra-fast clustering method enabling planetary-scale organization of protein space, scaling to trillions of sequences while retaining sensitivity at low identity.
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