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Prognostic Impact of Chromosome 1q Gain/Amplification in Multiple Myeloma Treated With Daratumumab-Based Regimens
1 Introduction Multiple myeloma (MM) is a genomically heterogeneous plasma cell (PC) malignancy in which cytogenetic abnormalities (CAs) strongly influence disease biology and outcomes. Among these, gain or amplification of chromosome arm 1q (+1q) is one of the most frequent with prevalence rising from newly diagnosed (ND) to relapsed/refractory (RR) disease and clonal size expanding with progression, reflecting clonal evolution under selective therapeutic pressure [1, 2].
Changes in Respiratory Viruses’ Activity in Children During the COVID-19 Pandemic: A Systematic Review
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Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity
Objective Pediatric obesity is associated with insulin resistance, which, in turn, impacts glucose and lipid metabolism. This study sought to assess how glucose variability relates to intrahepatic fat content, β cell insulin sensitivity, and glycolysis in youth with obesity. Methods A total of 27 youth with obesity (11 girls, BMI percentile, median [25th–75th percentiles]: 99.0 [97.9–99.0]) wore a continuous glucose monitoring device for 10 days and underwent a 3-h oral glucose tolerance test.
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