Recent phase 3 data presented at the 2025 San Antonio Brest Cancer Symposium (SABCS) point to evolving standards of care in breast cancer. Here are some of the highlights. Phase 3 data from the IidERA trial presented at SABCS 2025 suggest the investigational oral selective estrogen receptor degrader giredestrant may represent the first major advance in adjuvant endocrine therapy for early-stage ER-positive, HER2-negative breast cancer in more than two decades.