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Emily Han

As seen in: Medium, Wirecutter, Yahoo Life, Emerging Infectious Diseases, Nature, Wiley Online Library, Aol, Royal Society of Chemistry, The Kitchn, Apartment Therapy and
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Articles

Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination

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By Dongyoon Kim, Ningqiang Gong, Mohamad-Gabriel Alameh, Emily Han, Hanxun Wang, Jinjin Wang, Ellie Feng, Il-Chul Yoon, Amanda Murray, Qiangqiang Shi, So-Jeong Moon, Kaitlin Mrksich, Drew Weissman, Michael Mitchell
| Nature Verified
Abstract Modulating metabolism in immune cells is an effective approach to induce desired immune responses. Here we develop a lipid nanoparticle (LNP) capable of metabolic reprogramming of dendritic cells for mRNA vaccine applications. Using imidoester-based conjugation chemistry, we design a crosslinked ionizable lipid, C12-2aN, which possesses intrinsic metabolic modulatory properties.
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High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain

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By Emily Han, Dongyoon Kim, Amanda Murray, Kaitlin Mrksich
| dx.doi.org
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Author Correction: Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering | Nature Communications

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By Marshall Padilla, Kaitlin Mrksich, Yiming Wang, Rebecca M. Haley, Jacqueline Li, Emily Han, Rakan El-Mayta, SOFIA DIAS, Ningqiang Gong, Xuexiang Han, Vivek Chowdhary, Lulu Xue, Hannah M. Yamagata, James WIlson, James Wilson, Ravi Radhakrishnan
| Nature Verified
Correction to: Nature Communications https://doi.org/10.1038/s41467-024-55137-6, published online 24 January 2025 In the version of the article initially published, the “E4t-200” image in Fig. 4o was a duplicate of the “C12-200” image in the same panel. Fig. 4o has now been amended with the correct “E4t-200” image in the HTML and PDF versions of the article.
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