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Emily Magness on Muck Rack

Emily Magness

As seen in: MDPI, Texas Medical Center
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Articles

"Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Cro" by Prema Robinson, Emily Magness et al.

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By Prema Robinson, Emily Magness, Kelsey Montoya, Nikita Engineer
| Texas Medical Center
Abstract Crohn's disease (CD), is an inflammatory bowel disease that can affect any part of the gastro-intestinal tract (GI) and is associated with an increased risk of gastro-intestinal cancer. In the current study, we determined the role of genetic and small-molecule modulation of STAT3 in a mouse model of CD. STAT3 has 2 isoforms (α, β) which are expressed in most cells in a 4:1 ratio (α: β). STAT3α has pro-inflammatory and anti-apoptotic functions, while STAT3β has contrasting roles.
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"Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse M" by Prema Robinson, Kelsey Montoya et al.

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By Prema Robinson, Kelsey Montoya, Emily Magness, Emma Rodríguez
| Texas Medical Center
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) predisposes to colorectal cancer (CRC). In the current studies, we used the dextran sodium sulfate (DSS) murine model of colitis, which is widely used in preclinical studies, to determine the contribution of STAT3 to IBD. STAT3 has two isoforms: (STAT3 α; which has pro-inflammatory and anti-apoptotic functions, and STAT3β; which attenuates the effects of STAT3α).
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Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis

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By Prema Robinson, Emma Rodríguez, Kelsey Montoya, Emily Magness
| MDPI
Abstract : Simple Summary We used the dextran sodium sulfate (DSS) murine model of colitis, which is widely used in preclinical studies, to determine the contribution of STAT3 to IBD. STAT3 has two isoforms: (STAT3α; which has pro-inflammatory and anti-apoptotic functions, and STAT3β; which attenuates the effects of STAT3α).
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