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Articles by Emma O’Leary
Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated α-synuclein
Membrane association of α-synuclein (α-syn), a neuronal protein associated with Parkinson's disease (PD), is involved in α-syn function and pathology. Most previous studies on α-syn–membrane interactions have not used the physiologically relevant N-terminally acetylated (N-acetyl) α-syn form nor the most naturally abundant cellular lipid, i.e. phosphatidylcholine (PC). Here, we report on how PC membrane fluidity affects the conformation and aggregation propensity of N-acetyl α-syn.
Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated α-synuclein
Membrane association of α-synuclein (α-syn), a neuronal protein associated with Parkinson’s disease (PD), is involved in α-syn function and pathology. Most previous studies on α-syn–membrane interactions have not used the physiologically relevant N-terminally acetylated (N-acetyl) α-syn form nor the most naturally abundant cellular lipid, i.e. phosphatidylcholine (PC). Here, we report on how PC membrane fluidity affects the conformation and aggregation propensity of N-acetyl α-syn.
Civil Service and HSBC bosses: D&I still has far to go
Leaders should help to create cultures that are truly inclusive, which may mean admitting to uncomfortable truths Leaders mustn’t forget the simple things when it comes to D&I, according to Sue Owen, Civil Service diversity champion and permanent secretary at the Department for Digital, Culture, Media and Sport.
The 12 months of 2017: April
For our 12 Days of Christmas countdown we look at the most interesting HR happenings over the last year From 6 April this year, all firms with a pay bill over £3 million each year were obliged to pay the apprenticeship levy. It equates to 0.5% of an employer's annual wage bill and is paid through HMRC. Kathleen Henehan, research and policy analyst at the Resolution Foundation, warned that focus must be given to the quality of apprenticeships as well as quantity.
The 12 months of 2017: February
For our 12 Days of Christmas countdown we look at the most interesting HR happenings over the last year Legal cases over the status of workers in the gig economy continued to make headlines in 2017. When Gary Smith wanted to reduce his working days at Pimlico Plumbers following a heart attack, the Court of Appeal agreed with a tribunal that said he was entitled to basic workers' rights although he was technically self-employed.
Should employers change Christmas parties to avoid harassment claims?
If you make boundaries and expectations clear then the standard is set It’s the time of year when we usually focus on the dos and don’ts of the work Christmas party. However, with new sexual harassment allegations hitting the headlines almost daily, companies seem to be feeling more anxious about exposing themselves to the possibility of such a claim stemming from festive work gatherings.
Quarter would consider AI to tackle unconscious bias
AI to tackle bias in recruitment is on the rise but HR professionals should be cautious how they approach it A quarter (25%) of UK companies would consider using artificial intelligence (AI) to tackle unconscious bias in recruitment, with a fifth (20%) of organisations already using the technology, the Adecco Group has revealed.
HR news, jobs & blogs
Talent management and retention ‘is HR’s biggest challenge’ in the Middle East New survey data from Hays has revealed that HR directors in the Middle East believe managing and retaining talent will be the profession’s biggest challenge over the next two years. Sixty per cent of those polled for the DNA of an HR Leader report – published in association with CIPD Middle East – said it would be their most significant area of focus during that time.
HR news, jobs & blogs
Employee voice now a crucial part of modern recruitment, say experts Tech firms dominate the 2017 list of most recommended UK employers, with Facebook grabbing the top spot, in a Glassdoor survey released today. Analysis of data from former and current staff members, who voluntarily reviewed and rated the companies they work for, revealed that 90 per cent of Facebook employees would recommend the company to a friend.
HR news, jobs & blogs
As rapid technological advances change how we work, employees will lean on L&D professionals for support, writes Barry Johnson You probably learned about the industrial revolution at school. It was the transition to new manufacturing processes from about 1760 to about 1840, entailing the move from hand production to machines; the growth of manufacturing and iron production processes; the use of steam power; and the rise of the factory system.
HR news, jobs & blogs
A recent report by the women and equalities committee revealed that 54,000 women lost their jobs in 2015 as a result of pregnancy discrimination, and that pregnant women and mothers are subject to more discrimination today than they were 10 years ago. The committee proposed various recommendations and new legislation to protect pregnant employees and mothers from being treated less favourably than their childfree or male comparators.
HR news, jobs & blogs
Ex-offenders being ‘locked out of the labour market’ under current system Ex-offenders could have their criminal records sealed so they cannot be scrutinised by potential employers, under proposals published in a government-commissioned review today.
HR news, jobs & blogs
Report reveals BBC move to Salford created a fraction of the jobs hoped for The government is being urged not to overestimate the benefit of moving jobs outside London, after research revealed that the BBC’s Salford move six years ago had created less than a third of the jobs predicted.
HR news, jobs & blogs
Legal expert Emma O’Leary reviews the latest cases in this area, and offers tips on how to handle claims Discrimination in the workplace is never far from the headlines. The BBC was recently accused of discrimination when a significant gender pay gap was revealed among its highest earners.
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