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Emma Tobarra-López on Muck Rack

Emma Tobarra-López

As seen in: Nature
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Articles

Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC

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By Yiming Peng-Winkler, Xiao-Zheng Liu, Charlotte Girondel, Sebastian Igelmann, Sara Rotter, Michail Doukas, Ming Liu Verified, Anke Vandekeere, Melanie Planque, Juan Fernández-Garcia, Sébastien Tabariès, Sandra Martínez-Martín, Margherita Demicco, Ines Vermeire, Janine Theile, Dorien Broekaert, Tom Luedde, Peter Vermeulen, Daniele V. F. Tauriello, Raquel Perez-Lopez, Steve Stegen, Laura Soucek, Tiago de Oliveira, Lena-Christin Conradi, Peter Siegel, Cornelis Verhoef, Sarah-Maria Fendt, Sanne M. L. Verheul, Marta Buetas-Arcas, Florian Döbbe, Johannes Ceuppens, Jonas Haesevoets, Emma Tobarra-López, Johannes Georg Bode
| Nature Verified
Abstract Patients with colorectal cancer (CRC) frequently develop liver metastases1,2,3. The prognosis of these patients is skewed by the histopathological heterogeneity of their liver metastases4,5. Patients with ‘replacement’ metastases have a 5-year overall survival of less than 44.2%, compared with 73.4% in patients with ‘encapsulated’ (previously known as desmoplastic) metastases5; yet there are currently no approved therapies targeting replacement liver metastases.
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