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Articles by Emma Wright
An episignature informed systematic analysis to ascertain the clinical significance and consequences of CHD8 missense variants
Abstract Pathogenic CHD8 variants cause autosomal dominant ‘Intellectual developmental disorder with autism and macrocephaly’ (IDDAM) and are amongst the most common monogenic causes of autism. The clinical significance of CHD8 missense variants (MVs) frequently remains uncertain. Systematically applying ACGS/ACMG guidelines to 36 CHD8 MVs in 39 affected patients, only two variants were classified likely pathogenic (LP), with the remaining 34 classified variants of uncertain significance (VUS).
EU AI Act, GDPR, And Digital Laws Changes Proposed
CM Crowell & Moring LLP More Our founders aspired to create a different kind of law firm when they launched Crowell & Moring in 1979. From those bold beginnings, our mission has been to provide our clients with the best services of any law firm in the world through a spirit of trust, respect, cooperation, collaboration, and a commitment to giving back to the communities around us. Proposed amendments would alter a raft of key AI, data and digital laws.
The UK's Cyber Security & Resilience Bill At A Glance
CM Crowell & Moring LLP More Our founders aspired to create a different kind of law firm when they launched Crowell & Moring in 1979. From those bold beginnings, our mission has been to provide our clients with the best services of any law firm in the world through a spirit of trust, respect, cooperation, collaboration, and a commitment to giving back to the communities around us.
The Middle East's Big Bet On Artificial Intelligence And Data Security
The states of the Persian Gulf are moving rapidly to establish themselves as global centers of investment and innovation in artificial intelligence (AI). The Kingdom of Saudi Arabia, the United Arab Emirates (UAE), and the State of Qatar are making substantial outlays in technology and infrastructure as they seek to diversify their economies away from oil.
A Special Relationship Reboot? The US-UK Tech Prosperity Deal
CM Crowell & Moring LLP More Our founders aspired to create a different kind of law firm when they launched Crowell & Moring in 1979. From those bold beginnings, our mission has been to provide our clients with the best services of any law firm in the world through a spirit of trust, respect, cooperation, collaboration, and a commitment to giving back to the communities around us.
Children First: How Ofcom's Children's Code And Age Checks Change The Digital Game
Ofcom, the UK's communications and appointed online safety regulator, is following through on its commitment to protect children online. From 25 July 2025, Ofcom will enforce its Protection of Children Codes of Practice (the "Code") under the Online Safety Act 2023 - a significant milestone for digital safety in the UK. The Code sets a new standard for safeguarding children in the digital world.
A developmental program of early residency promotes the differentiation of divergent uterine NK cell subsets in humans
Abstract Human uterine natural killer cells (uNKs) are a tissue-resident, innate lymphocyte population that have critical roles in supporting pregnancy health. uNKs derive from circulatory cells in the peripheral blood which immigrate into the endometrium and become resident as they reconstitute the uterine lining after menses. How tissue-resident uterine NK cells arise from blood-based precursor cells is unknown.
Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplant - Nature Communications
Abstract Pig-to-human xenotransplantation is rapidly approaching the clinical arena; however, it is unclear which immunomodulatory regimens will effectively control human immune responses to pig xenografts. Here, we transplant a gene-edited pig kidney into a brain-dead human recipient on pharmacologic immunosuppression and study the human immune response to the xenograft using spatial transcriptomics and single-cell RNA sequencing.
Are you a victim of data bias?
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How can a shared care record deliver better personalised care planning?
Ben Wilson discusses the progress, benefits, and future possibilities for an integrated, patient-centric healthcare system For many years the NHS has talked about the need to shift to a more personalised approach to health and care.
Using technology to engage customers and build loyalty
Technology is rapidly evolving and customer experience has never been more important. How can shopping centres stay ahead of the curve in today’s changing landscape? This article forms part of a special feature, first published in SCN’s Little Guns edition.
Successful launch for Valleyside Barn as hundreds flock to Food & Drinks Fair
New weddings and events venue, Valleyside Barn, based in Bickleigh have officially launched with a ribbon cutting ceremony followed by a local Food & Drinks Fair attended by around 300 people. Emma Wright, Partner of Valleyside Barn & Escapes said, “The launch was a huge success and we’ve been overwhelmed by the fantastic feedback on the barn from attendees.
Data Security During The Coronavirus Crisis – The Lessons Behind The Breaches - Privacy - UK
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P044: Do expected benign breast pathologies require a follow-up clinic appointment?
Introduction: It is a standard practice to bring back all patients who have had a biopsy for suspicious breast lesions to the results clinic. However, variations exist when it comes to patients with expected benign results. The aim of this project was to improve the efficiency of our results clinic by offering patients, who are expected to have benign breast pathologies a choice between a letter or a follow-up appointment.
Definition and delivery of an aortopathy bundle of care (ABC): a tool for improving diagnosis and management of Marfan syndrome and related conditions
To accelerate diagnosis and improve management of Marfan syndrome and related conditions, a multidisciplinary improvement science project was developed between cardiology and genomic medicine. Local experience suggested potential for improvement in the delivery of care for patients with Marfan syndrome and related conditions. Under the prevailing system, patients required separate clinical genetic and cardiological assessments.
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