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Emmanouill Stylianakis on Muck Rack

Emmanouill Stylianakis

As seen in: Nature
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Articles

Prohibitin 2 is a key regulator of T cell proliferation, differentiation, and effector functions in vivo

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By Johannes Vogt, Carsten Merkwirth, Petra Adams-Quack, David C. Uhlfelder, Thomas Michna, Assel Nurbekova, Ute Distler, Liliana Rojas-Charry, Hajime Yurugi, Sonja Reißig, F. Thomas Wunderlich, Krishnaraj Rajalingam, Stefan Tenzer, Axel Methner, Thomas Langer, Ari Waisman, Nadine Hövelmeyer, Elena Zurkowski, Emmanouill Stylianakis
| Nature Verified
Abstract Prohibitin 2 (PHB2) is a highly conserved protein with essential roles in cell homeostasis and survival across different cell types. Previous studies have shown that the deletion of PHB2 results in an arrest in proliferation due to impaired mitochondrial function regulated by the dynamin-like GTPase OPA1. The function of PHB2 in immune cells remains unclear; however, some studies suggest that PHB2 plays a role in the cell membranes of B and T cells.
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