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Emmanuel Labaronne on Muck Rack

Emmanuel Labaronne

As seen in: Nature, BioRxiv, Genome Research
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Articles

Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling - Nature Communications

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By Lisa Bertrand, Annika Nelde, Bertha Cecilia Ramirez, Isabelle Hatin, Hugo Arbes, Emmanuel Labaronne, Didier Decimo, Guillaume Beauclair, Joelle Vinh, Sylvain Cardinaud, Cecile Gouttefangeas, Marcus Altfeld, Laurent Hocqueloux, Brigitte Autran, Hans-Georg Rammensee, Emiliano P. Ricci, Juliane S. Walz, Olivier Namy
| Nature Verified
Abstract The development of ribosomal profiling (Riboseq) revealed the immense coding capacity of human and viral genomes. Here, we used Riboseq to delineate the translatome of HIV-1 in infected CD4+ T cells. In addition to canonical viral protein coding sequences (CDSs), we identify 98 alternative open reading frames (ARFs), corresponding to small Open Reading Frames (sORFs) that are distributed across the HIV genome including the UTR regions.
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Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression - Nature Communications

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By Emmanuel Labaronne, Didier Decimo, Lisa Bertrand, David Cluet, Isabelle Hatin, Brigitte Autran, Lucie Etienne, Caroline Goujon, Jean-Christophe Paillart, Bertha Cecilia Ramirez, Olivier Namy, Arnaud Moris
| Nature Verified
Abstract Human immunodeficiency virus type-1 (HIV-1) is a complex retrovirus that relies on alternative splicing, translational, and post-translational mechanisms to produce over 15 functional proteins from its single ~10 kb transcriptional unit. Using ribosome profiling, nascent protein labeling, RNA sequencing, and whole-proteomics of infected CD4 + T lymphocytes, we characterized the transcriptional, translational, and post-translational landscape during infection.
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Translation-dependent and -independent mRNA decay occur through mutually exclusive pathways defined by ribosome density during T cell activation

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By Blandine Mercier, Emmanuel Labaronne, David Cluet, Laura Guiguettaz
| Genome Research
2 1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA; 2Laboratory of Biology and Modeling of the Cell (LBMC), Université de Lyon, ENS de Lyon, Université Claude Bernard, CNRS UMR 5239, Inserm U1293, 69007 Lyon, France; 3ADLIN Science, 9100 Evry-Courcouronnes, France; 4Centre International de Recherche en Infectiologie Université de Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007 Lyon, France ↵5...
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