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Emmy Sakakibara on Muck Rack

Emmy Sakakibara

As seen in: BioRxiv
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Articles

Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice

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By Allen Pan, Mickael Audrain, Rajeev Joshi, Emmy Sakakibara
| BioRxiv
Abstract Background: Dual specificity protein phosphatase 6 (DUSP6) was recently identified as a key hub gene in a causal network that regulates late-onset Alzheimer′s disease. Importantly, decreased DUSP6 levels are correlated with an increased clinical dementia rating in human subjects, and DUSP6 levels are additionally decreased in the 5xFAD amyloidopathy mouse model.
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