Emrah Ilker Ozay

Squeezed cells prime antitumor activity in a mouse model of human papillomavirus 16–positive tumors To demonstrate that the Ag-presenting capacity of squeezed cells could elicit an antitumor CD8+ T cell response with relevance to a human tumor, T cells, B cells, or a PBMC surrogate were squeezed with an SLP derived from the human papillomavirus 16 (HPV16) E7 protein. This E7 SLP spans the immunodominant H2-Db-restricted epitope, RAHYNIVTF (20), and allows immunization of C57BL/6 mice.

Open Access Matthew G. Booty, Kelan A. Hlavaty, Adam Stockmann, Emrah Ilker Ozay, Carolyne Smith, Lina Tian, Edylle How, Disha Subramanya, Anita Venkitaraman, Christian Yee, Olivia Pryor, Kelly Volk, Katarina Blagovic, Ildefonso Vicente-Suarez, Defne Yarar, Melissa Myint, Amy Merino, Jonathan Chow, Tarek Abdeljawad, Harry An, Sophia Liu, Shirley Mao, Megan Heimann, LeeAnn Talarico, Miye K. Jacques, Eritza Chong, Lucas Pomerance, John T. Gonzalez, Ulrich H. von Andrian, Klavs F.

Humanized antibodies are increasingly gaining attention for their therapeutic potential in immunotherapy but, to date, the collection of cellular targets has been limited to those that are secreted from cells or are expressed on the cell surface. This approach leaves a wealth of intracellular proteins unexplored as potential targets.