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Endre Barta

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Articles

Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis - Nature Communications

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By Tamas Nagy, Serena Carra, Endre Barta
| Nature Verified
Abstract During muscle cell differentiation, the alternatively spliced, acidic β-domain potentiates transcription of Myocyte-specific Enhancer Factor 2 (Mef2D). Sequence analysis by the FuzDrop method indicates that the β-domain can serve as an interaction element for Mef2D higher-order assembly. In accord, we observed Mef2D mobile nuclear condensates in C2C12 cells, similar to those formed through liquid-liquid phase separation.
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