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Engin H. Serpersu on Muck Rack

Engin H. Serpersu

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Articles

A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad

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By Matthew J. Cuneo, Prashasti Kumar, Engin H. Serpersu
| Science Magazine Verified
One group of enzymes that confer resistance to aminoglycoside antibiotics through covalent modification belongs to the GCN5-related N-acetyltransferase (GNAT) superfamily. We show how a unique GNAT subfamily member uses a previously unidentified noncanonical catalytic triad, consisting of a glutamic acid, a histidine, and the antibiotic substrate itself, which acts as a nucleophile and attacks the acetyl donor molecule.
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