CDC strongly recommends Yeztugo for PrEP The U.S. Centers for Disease Control and Prevention (CDC) now recommends Yeztugo for HIV prevention as PrEP (pre-exposure prophylaxis). “On the basis of a high certainty of evidence for its efficacy and safety derived from the agency's analysis, CDC strongly recommends [Yeztugo]…,” the agency reported in its September 18 Morbidity and Mortality Weekly Report (MMWR).