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Enish Pathak on Muck Rack

Enish Pathak

As seen in: BioRxiv
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Articles

Interleukin-1 receptor antagonist is a conserved factor for exacerbating tuberculosis susceptibility

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By Ophelia V Lee, Sujhey Hernández-Bazán, Enish Pathak
| BioRxiv
Abstract Mycobacterium tuberculosis (Mtb) causes 1.25 million deaths a year; however, tuberculosis (TB) pathogenesis remains poorly understood. Here we find that gene signatures from three different Mtb-susceptible mouse models predict active TB disease in humans significantly better than a signature from resistant C57BL/6 (B6) mice. Conserved among susceptible mice, non-human primates, and humans, but largely absent from B6 mice, was Mtb-induced Spp1+ macrophage differentiation.
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