Enmao Yin

Regulating Tumor Glycometabolism and Immune Microenvironment by Inhibiting Lactate Dehydrogenase with Platinum(IV) Complexes Suxing Jin, Enmao Yin, Chenyao Feng, Yuewen Sun, Tao Yang, Hao Yuan, Zijian Guo and Xiaoyong Wang Abstract Lactate dehydrogenase (LDH) is a key enzyme involved in the process of glycolysis, assisting cancer cells to take in glucose and generate lactate, as well as to suppress and evade the immune system by altering the tumor microenvironment (TME).

Immunogenicity and cytotoxicity of a platinum(iv) complex derived from capsaicin† Yuewen Sun,a Enmao Yin,a Yehong Tan,a Tao Yang,a Dongfan Song,b Suxing Jin, *b Zijian Guo b and Xiaoyong Wang *a Author affiliations * Corresponding authors a State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R.

Immunogenicity and cytotoxicity of a platinum(IV) complex derived from capsaicin Platinum-based anticancer drugs constitute the major cornerstone of chemotherapy for various cancers. Although cytotoxic agents are considered to have immunosuppressive effects, increasing evidences suggest that some cytotoxic compounds can effectively stimulate the antitumor immune response by inducing a special apoptosis called immunogenic cell death (ICD).