Enoch Asimbisa

There are several challenges for structure elucidation work that remain most common in literature. Two of them seem particularly ubiquitous: (i) misassignment of stereoconfiguration in diastereomers, especially, the cases of quaternary stereogenic centers, where the difference in 13C chemical shifts for two epimers could be subtle, and (ii) errors in stereoconfiguration or atom connectivity in molecules containing heavy atoms, for example such heavy halogens as bromine or iodine.

Introduction Click to copy section linkSection link copied! This paper represents the second installment in our ongoing efforts focused on organic structure elucidation and revision outside the realm of natural products. Such corrections frequently carry significant implications for physical organic chemistry and reaction mechanisms.