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Nucleobase Amino Acids in the Development of Amide-Linked Oligonucleotide Mimics
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. References 1, , , and , “Analysis of Binding Properties of Pathogens and Toxins Using Multivalent Glycan Microarrays,” RSC Advances 8 (2018): 14898–14905.
Nucleobase Amino Acids in the Development of Amide-Linked Oligonucleotide Mimics
1 Introduction Targeting cellular RNAs for therapeutic interventions is being vigorously pursued worldwide in recent years [1]. One such approach involving the antisense principle has emerged as an asset in the development of potential therapeutic agents by controlling protein synthesis at the nucleic acid level [2]. The short (12–24-mers) chemically modified antisense oligonucleotides (ASOs) modulate the function of cognate mRNA in cells by Watson–Crick base-pairing.
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