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Ercan Cacan

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Articles by Ercan Cacan

Twist1 Regulates the Immune Checkpoint VISTA and Promotes the Proliferation, Migration and Progression of Pancreatic Cancer Cells

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By Ercan Cacan
| Wiley Online Library Verified
1 Introduction Pancreatic cancer is one of the main causes of cancer-related deaths worldwide. In the last 25 years, the global incidence of pancreatic cancer has surged by more than two-fold and the 5-year survival rate is about 11%, despite advancements in cancer treatment [1, 2]. The low survival rate is due to late diagnosis, limited treatment options, and resistance mechanisms of tumours.
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Severe and post-COVID-19 are associated with high expression of vimentin and reduced expression of N-cadherin - Scientific Reports

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By Ercan Cacan
| Nature Verified
Abstract SARS-CoV-2 penetrates human cells via its spike protein, which mainly interacts with ACE2 receptors, triggering viral replication and an exacerbated immune response characterized by a cytokine storm. Vimentin III, an intermediate filament protein predominantly found in mesenchymal cells, has garnered considerable attention in recent research due to its multifaceted biological roles and significance in the endothelial-mesenchymal transition (EndMT) during various fibrotic processes.
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13. AmpliconSuite: Analyzing focal amplifications in cancer genomes

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By Caglar Berkel, Ercan Cacan, Anna Valentine, Ruben C. Petreaca
| ScienceDirect Verified
Focal amplifications in cancer genomes, particularly extrachromosomal DNA (ecDNA) amplifications, are pivotal in cancer progression, enabling high amplification of oncogenes. Distinguishing the different mechanisms with whole-genome sequencing (WGS) data is challenging due to their complex profiles of copy number (CN) and structural variation (SV). We present AmpliconSuite, a collection of tools enabling robust identification of focal amplifications from WGS data.
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Analysis of longevity in Chordata identifies species with exceptional longevity among taxa and points to the evolution of longer lifespans

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By Tokat Gaziosmanpasa, Caglar Berkel, Ercan Cacan
| link.springer.com
Abstract Animals have a considerable variation in their longevity. This fundamental life-history trait is shaped by both intrinsic and extrinsic mortality pressures, influenced by multiple parameters including ecological variables and mode-of-life traits. Here, we examined the distribution of maximum age at multiple taxonomic ranks (class, order and family) in Chordata, and identified species with exceptional longevity within various taxa.
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