Erdenetsogt Dungubat

1. Introduction Nonalcoholic fatty liver disease (NAFLD) is characterized by an excessive fat accumulation in the livers of patients without a history of alcohol abuse. NAFLD is classified as either simple steatosis (nonalcoholic fatty liver) or nonalcoholic steatohepatitis (NASH). The former is characterized by hepatic steatosis, while the latter is characterized by steatosis, inflammation, and hepatic cell injury.

Loading metrics Open Access Peer-reviewed Research Article Abstract According to previous clinical studies, the prevalence of non-alcoholic fatty liver disease (NAFLD) is higher in men than women only during the reproductive age. Animal models of NAFLD that reflect sex differences in humans have not been established. In this study, we examined sex differences in the hepatic lesions of Tsumura Suzuki obese diabetes (TSOD) and db/db mice, which are representative genetic models of NAFLD.