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Articles by Eric Alsop
A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver
Keywords metabolic dysfunction-associated steatotic liver disease non-alcoholic fatty liver disease proteomics diabetes liver-on-a-chip Introduction Metabolic-associated steatotic liver disease (MASLD)—affecting over 30% of individuals worldwide1—has emerged as a predominant driver of end-stage liver disease and an important contributor to a range of other chronic, life-limiting illnesses (e.g., cancer,2 cardiovascular disease,3 and renal dysfunction).4 MASLD presents a histological spectrum...
Decreased SNCA Expression in Whole-Blood RNA Analysis of Parkinson's Disease Adjusting for Lymphocytes
Abstract Blood-based RNA transcriptomics offers a promising avenue for identifying biomarkers of Parkinsons Disease (PD) progression and may provide mechanistic insights into the systemic biological processes underlying its pathogenesis beyond the well-defined neurodegenerative features. Previous studies have indicated an age-dependent increase in neutrophil-enriched gene expression, alongside a reduction in lymphocyte counts, in individuals with PD.
Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease - Nature Communications
Abstract The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the study of Alzheimer’s disease (AD). Integration with complementary multiomics data such as genetics, proteomics and clinical data provides powerful opportunities to link cell subpopulations and molecular networks with a broader disease-relevant context.
Small RNA Changes in Plasma Have Potential for Early Diagnosis of Alzheimer’s Disease before Symptom Onset
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A public resource of single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease
Abstract The emergence of technologies that can support high-throughput profiling of single cell transcriptomes offers to revolutionize the study of brain tissue from persons with and without Alzheimer's disease (AD). Integration of these data with additional complementary multiomics data such as genetics, proteomics and clinical data provides powerful opportunities to link observed cell subpopulations and molecular network features within a broader disease-relevant context.
Cryopreservation of cerebrospinal fluid cells preserves transcriptomics integrity for single-cell analysis
Abstract Cerebrospinal fluid (CSF) matrix biomarkers have become increasingly valuable surrogate markers of neuropsychiatric diseases in research and clinical practice. In contrast, CSF cells have been rarely investigated due to their relative scarcity and fragility, and lack of common collection and cryopreservation protocols, with limited exceptions for neurooncology and primary immune-based diseases like multiple sclerosis.
Dysregulation of Principal Circulating miRNAs in Non-human Primates Following Ischemic Stroke
Introduction Circulating microRNAs (miRNAs) might be useful as surrogate biomarkers for the diagnosis or prognosis of pathological conditions such as acute stroke; finding early blood miRNA biomarkers to diagnose this disease, for instance, could drastically reduce treatment delays. In addition, emerging RNA therapeutics targeting mRNAs have already been approved by the Food and Drug Administration for clinical research (Erdos et al., 2021) and have gained attention in cerebrovascular research.
Activated iPSC-microglia from C9orf72 ALS/FTD patients exhibit endosomal-lysosomal dysfunction
Activated iPSC-microglia from C9orf72 ALS/FTD patients exhibit endosomal-lysosomal dysfunction Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M Gittings, Benjamin E Rabichow, Deepti Lall, Stephen Moore, Lynette Bustos, Ryan Pevey, Camelia Burciu, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Robert Bowser, Tara L Spires-Jones, Mathew Blurton-Jones, Tania F Gendron, Robert H Baloh, Kendall Van Keuren-Jensen, Rita...
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