Ivo Violich on Muck Rack

Ivo Violich

As seen in: The American Journal of Human Genetics
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Articles

Decreased SNCA Expression in Whole-Blood RNA Analysis of Parkinson's Disease Adjusting for Lymphocytes

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By Kayla Xu, Elizabeth Hutchins, Eric Alsop, Ivo Violich
| biorxiv.org
Abstract Blood-based RNA transcriptomics offers a promising avenue for identifying biomarkers of Parkinsons Disease (PD) progression and may provide mechanistic insights into the systemic biological processes underlying its pathogenesis beyond the well-defined neurodegenerative features. Previous studies have indicated an age-dependent increase in neutrophil-enriched gene expression, alongside a reduction in lymphocyte counts, in individuals with PD.
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