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Eric Andy Cardona on Muck Rack

Eric Andy Cardona

As seen in: BioRxiv
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Articles

Non-apoptotic role of EGL-1 in exopher production and neuronal health in Caenorhabditis elegans

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By Zheng Wu, Jon Pierce, Eric Andy Cardona
| BioRxiv
Abstract While traditionally studied for their pro-apoptotic functions, recent research suggests BH3-only proteins also have non-apoptotic roles. Here, we find that EGL-1, the BH3-only protein in Caenorhabditis elegans, promotes the cell-autonomous production of exophers in adult neurons. Exophers are large, micron-scale vesicles that are ejected from the cell and contain cellular components such as mitochondria.
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