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Articles by Eric Giannoni
Beyond accuracy: translating machine learning risk models into meaningful clinical decision support in neonatal intensive care
Machine learning (ML) approaches for neonatal sepsis detection have proliferated rapidly over the past decade.1 Yet, despite growing enthusiasm, only one predictive monitoring system has demonstrated improved clinical outcomes in a randomized trial.2 The central challenge facing neonatal ML is therefore no longer whether algorithms can predict adverse events, but whether they improve clinical decision-making and patient outcomes.
Neonatal sepsis and cardiovascular dysfunction II: assessment
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Neonatal sepsis-induced cardiovascular dysfunction includes impaired myocardial function (which may be systolic and/or diastolic) and vasoregulatory failure (which may lead to vasodilation or vasoconstriction). The haemodynamic response in neonatal sepsis may therefore be hyperdynamic or hypodynamic, and the underlying pathophysiological mechanisms are heterogenous. The assessment of the neonate with sepsis and cardiovascular dysfunction is critical for targeted pathophysiology-based management.
By Sophie Duignan, Satyan Lakshminrusimha, Kathryn Armstrong, Michaela Pentony, Tobias Strunk, Marina Degtyareva, Eric Giannoni, Joseph M. Bliss, H. Rob Taal, Claus Klingenberg, Lars Navér, Jan Janota, Agnes van den Hoogen, Orla Franklin, Eleanor J Molloy, Franz B. Plötz, Helmut Küster, Willem P. de Boode
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Nature
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Antibiotic exposure for culture-negative early-onset sepsis in late-preterm and term newborns: an international study - Pediatric Research
Abstract Early-life antibiotic exposure is disproportionately high compared to the burden of culture-proven early-onset sepsis (CP-EOS). We assessed the contribution of culture-negative cases to the overall antibiotic exposure in the first postnatal week. We conducted a retrospective analysis across eleven countries in Europe, North America, and Australia.
Sepsis shapes the human γδ TCR repertoire in an age‐ and pathogen‐dependent manner
Introduction Sepsis contributes to a major burden of disease in early life. Worldwide, it is estimated that half of the 48.9 million annual cases of sepsis occur in children, leading to 2.9 million deaths [1]. This vulnerability in early life is not unexpected, given the predominantly naïve phenotype of neonatal immune cells and distinctive immunological challenges at birth and during childhood [2-4].
In 2015, the UN adopted the Sustainable Development Goals (SDG) representing integrated actions to improve health, prosperity, and peace on the planet. SDG 3 focuses on health and specifically targets preventable neonatal deaths to achieve neonatal mortality below 12 per 1000 livebirths by 2030.
Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America, and Australia
Key Points Question What is the rate of exposure to antibiotics and the incidence of early-onset sepsis (EOS) and sepsis-associated mortality among late-preterm and full-term newborns? Findings In this cross-sectional study of 757 979 neonates born in 13 networks from 11 countries, 2.86% received antibiotics during the first postnatal week (range across networks, 1.18%-12.45%).
COVID-19 in pregnant women - Authors' reply
David Baud Eric Giannoni Eric Giannoni Affiliations Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland Search for articles by this author Léo Pomar Léo Pomar Affiliations Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, 1011 Lausanne, Switzerland Search for articles by this author Xiaolong Qi Karin Nielsen-Saines Karin Nielsen-Saines Affiliations Division...
Neonatal Sepsis of Early Onset, and Hospital-Acquired and Community-Acquired Late Onset: A Prospective Population-Based Cohort Study
Publication HistoryPublished online: July 24, 2018Accepted: May 30, 2018; Received in revised form: May 9, 2018; Received: March 19, 2018;
Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection
Congenital cytomegalovirus (cCMV) infections, with a global estimated prevalence of 0.6 to 0.7%, are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL) [1–6]. Cytomegalovirus (CMV) can be transmitted from the mother to the fetus despite pre-existing immunity [1–7], from either reactivation or reinfection [6].
Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study
Sepsis is a leading cause of childhood mortality worldwide. We assessed population-based incidence and outcomes of blood culture-proven bacterial sepsis in children in Switzerland. We did a multicentre, prospective, cohort study at ten paediatric hospitals in Switzerland. We included neonates and children younger than 17 years with blood culture-proven bacterial sepsis.
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