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Abstract The most common rRNA modification is 2’-O-methylation. Here, we determine the landscape of 2’-O-methylation in Leishmania, a parasite that cycles between two different hosts, insect and mammalian. We find two 2’-O-methylated positions that are differentially modified during the parasite’s two life stages.
Highlights Phenotypic plasticity of macrophages (Mϕs) and dendritic cells (DCs) enables these cells to adapt their immune functions to local tissue microenvironment changes. Leishmania exploits Mϕ and DC phenotypic plasticity to establish permissive conditions for intracellular survival and chronic infection. Mϕ polarization and DC maturation result from a complex regulatory relationship between epigenetic and transcriptional gene expression controls.
Highlights • Leishmania modulates H3 modification of macrophages in vitro and in vivo • Leishmania prevents NF-κB and NLRP3 activation in infected macrophages • Leishmania induces long-term transcriptomic modulations of NF-κB and NLRP3 pathways Summary Aberrant macrophage activation during intracellular infection generates immunopathologies that can cause severe human morbidity.
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