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Safety, Feasibility, and Merits of Longitudinal Molecular Testing of Multiple Metastatic Sites to Inform mTNBC Patient Treatment in the Intensive Trial of Omics in Cancer | JCO Precision Oncology

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By Kimberly A. Burton, Sibel Blau, Elisabeth Mahen, Eric Quentin Konnick
| ascopubs.org
Breast cancer (BC) is the most common malignancy in women worldwide excluding skin cancer.1 Triple-negative BC (TNBC), defined by features that it lacks—overexpression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)—comprises about 10% of BCs in non-Hispanic White women and 21% of BCs in non-Hispanic Black women.2 TNBC is more aggressive and is associated with a poorer survival at 5 years than other BC subtypes.3-5 Patients with...
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