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Articles

Examining the Three‐Dimensional Spatial Architecture of Mouse Amygdala Engram Ensembles

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By Emily Kramer Verified, eric yin, Paul W. Frankland, Anne Wheeler
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description hipo70056-sup-0001-FigureS1-S15.docxWord 2007 document , 8.2 MB Figure S1: Contextual fear memory test.
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Ultra-Fast Multi-Organ Proteomics Unveils Tissue-Specific Mechanisms of Drug Efficacy and Toxicity

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By Yun Xiong, Lin Tan, Wai-Kin Chan, eric yin
| BioRxiv
Abstract Rapid and comprehensive analysis of complex proteomes across large sample sets is vital for unlocking the potential of systems biology. We present UFP-MS, an ultra-fast mass spectrometry (MS) proteomics method that integrates narrow-window data-independent acquisition (nDIA) with short-gradient micro-flow chromatography, enabling profiling of >240 samples per day. This optimized MS approach identifies 6,201 and 7,466 human proteins with 1- and 2-min gradients, respectively.
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