Erica Olmann Saphire on Muck Rack

Erica Olmann Saphire

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A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection - Nature Communications

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By Nicole Lloyd, Caroline Atyeo, Hailee R. Perrett, Kathryn M. Hastie, Andrew Ward, Andrea Carfi, Erica Olmann Saphire
| Nature
Abstract Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case fatality rate. We have designed and generated lipid nanoparticle encapsulated, modified mRNA vaccines that encode for the wild-type Lassa virus strain Josiah glycoprotein complex or the prefusion stabilized conformation of the Lassa virus glycoprotein complex.
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