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Erica Seigneur on Muck Rack

Erica Seigneur

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Articles

GluD1 is a signal transduction device disguised as an ionotropic receptor

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By Jinye Dai, Christopher Patzke, Kif Liakath-Ali, Erica Seigneur
| Nature Verified
Abstract Ionotropic glutamate delta receptors 1 (GluD1) and 2 (GluD2) exhibit the molecular architecture of postsynaptic ionotropic glutamate receptors, but assemble into trans-synaptic adhesion complexes by binding to secreted cerebellins that in turn interact with presynaptic neurexins1,2,3,4. It is unclear whether neurexin–cerebellin–GluD1/2 assemblies serve an adhesive synapse-formation function or mediate trans-synaptic signalling.
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