Erika Hammarlund on Muck Rack

Erika Hammarlund

As seen in: Cell Reports Medicine
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Articles

Development of a hydrogen peroxide-inactivated vaccine that protects against viscerotropic yellow fever in a non-human primate model

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By Ian J. Amanna, Archana Della Thomas, Flora Engelmann, Erika Hammarlund
| Cell Reports Medicine Verified
Highlights • H2O2-based oxidation remains active longer than BPL-based virus inactivation • Site-directed oxidation maintains a conserved YFV-neutralizing epitope better than BPL • H2O2-inactivated yellow fever vaccines prevent yellow fever viremia • H2O2-inactivated yellow fever vaccines protect against lethal yellow fever Summary Yellow fever virus (YFV) is endemic in >40 countries and causes viscerotropic disease with up to 20%–60% mortality.
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