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Erika I Barth on Muck Rack

Erika I Barth

As seen in: Journal of Pharmacology and Experimental Therapeutics
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Articles

Exploiting the Receptor-Binding Domains of R-Spondin 1 to Target Leucine-Rich Repeat-Containin G-Coupled Protein Receptor 5-Expressing Stem Cells in Ovarian Cancer

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By Clara Wong, Maria Carmen Mulero, Erika I Barth, Katherine E. Wang
| Journal of Pharmacology and Experimental Therapeutics
Abstract Leucine-rich repeat-containing G-protein-coupled receptor (LGR5) and LGR6 mark epithelial stem cells in normal tissues and tumors. They are expressed by stem cells in the ovarian surface and fallopian tube epithelia from which ovarian cancer arises. High-grade serous ovarian cancer is unique in expressing unusually high levels of LGR5 and LGR6 mRNA. R-spondins are the natural ligands for LGR5 and LGR6 to which they bind with nanomolar affinity.
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Exploiting the receptor-binding domains of RSPO1 to target LGR5-expressing stem cells in ovarian cancer

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By Clara Wong, Maria Carmen Mulero, Katherine E. Wang, Erika I Barth
| Journal of Pharmacology and Experimental Therapeutics
Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas.
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