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The fixed cortical fraction assumption in Hip Structure Analysis produces systematic, sex- and age- dependent errors in femoral neck morphology estimates

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By erin r, Aerospace Engineering
| Frontiers
Abstract Hip Structure Analysis (HSA) estimates femoral neck morphology from dual-energy X-ray absorptiometry (DXA) images using simplifying assumptions, including that cortical bone accounts for a fixed 60% of total bone mineral content at the narrow neck (cortical fraction, fc = 0.6). The empirical basis of this assumption is poorly established, and its effect on HSA-derived structural parameters has not been systematically evaluated.
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