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Articles by Erming Wang
Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures
ResourceOnline nowOpen access Affiliations & Notes 1Departments of Structural Biology and Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, USA 2Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, Memphis, TN, USA 3Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Genomics Institute, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New...
The Landscape of Sex- and APOE Genotype-Specific Transcriptional Changes in Alzheimer's Disease at the Single Cell Level
Abstract Alzheimer's disease (AD) is the most common form of dementia, with approximately two-thirds of AD patients are females. Basic and clinical research studies show evidence supporting sex-specific differences contributing to the complexity of AD. There is also strong evidence supporting sex-specific interaction between the primary genetic risk factor of AD, APOE4 and AD-associated neurodegenerative processes.
Human brain aging heterogeneity observed from multi-region omics data reveals a subtype closely related to Alzheimer's disease
Abstract INTRODUCTION: The interconnection between brain aging and Alzheimer's disease (AD) remain to be elucidated. METHODS: We investigated multi-omics (transcriptomics and proteomics) data from multiple brain regions (i.e., the hippocampus (HIPP), prefrontal cortex (PFC), and cerebellum (CRBL)) in cognitively normal individuals. RESULTS: We found that brain samples could be divided into ADL (AD-like) and NL (normal) subtypes which were correlated across brain regions.
Proteomic profiling of intracranial atherosclerotic plaque in the human brain
Abstract Background: Intracranial atherosclerotic disease (ICAD) is one of the major causes of ischemic stroke and associated with high risk of stroke recurrence. There are no reliable and specific fluid biomarkers for ICAD, and little is known about the proteomic profiling of ICAD. In this study we aimed to explore the feasibility of applying proteomics technology to profile intracranial atherosclerotic plaques extracted from postmortem human brain arteries.
Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer’s Disease
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Proteomic signaling of dual specificity phosphatase 4 (DUSP4) in Alzheimer′s disease
Abstract DUSP4 is a member of the DUSP (Dual-Specificity Phosphatase) subfamily that is selective to the mitogen-activated protein kinases (MAPK) and has been implicated in a range of biological processes and functions in Alzheimer′s disease (AD).
Genome‐wide methylomic regulation of multiscale gene networks in Alzheimer's disease
2.5 DMR-associated genes and AD risk genes After determining the methylomic contributions to gene and protein expression, we investigated correlations between individual DMRs and gene or protein expression. A gene was correlated with a DMR if it was significantly correlated with the DMR at a Benjamini–Hochberg (BH)-adjusted P-value < 0.05. We took the union of all the genes with significant positive correlations with a given DMR as the DMR-positively associated gene signature (PAS) for that DMR.
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