Ermira Pazolli on Muck Rack

Ermira Pazolli

As seen in: Texas Medical Center
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Articles

Ecology of Two High Copy Plasmids

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By Ermira Pazolli, Alan Harker, Brigham Young
| scholarsarchive.byu.edu
Keywords ecology, plasmids, genetic entities, fluorescence Department Microbiology and Molecular Biology Abstract Plasmids are genetic entities residing in the cell. They can vary in size and genetic content. There are alternate views about plasmids, but the consensus one is that they are genetic elements that are transferred from cell to cell, thus conferring resistance or performing some other function advantageous to the cell.
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Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia

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By Andreas Varkaris, Hakan Gunaydin, Qi Wang, Ermira Pazolli
| Texas Medical Center
PIK3CA (PI3Kα) is a lipid kinase commonly mutated in cancer, including ∼40% of hormone receptor–positive breast cancer. The most frequently observed mutants occur in the kinase and helical domains. Orthosteric PI3Kα inhibitors suffer from poor selectivity leading to undesirable side effects, most prominently hyperglycemia due to inhibition of wild-type (WT) PI3Kα.
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