Essel Charles-Chess on Muck Rack

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Articles

Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria

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By Camila Marques-da-Silva, Clyde Schmidt-Silva, Carson Bowers, Essel Charles-Chess
| biorxiv.org
Abstract Plasmodium parasites undergo development and replication within the hepatocytes before infecting the erythrocytes and initiating clinical malaria. Although type-I interferons (IFNs) are known to hinder Plasmodium infection within the liver, the underlying mechanisms remain unclear. Here, we describe two IFN-I-driven hepatocyte antimicrobial programs controlling liver-stage malaria.
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