Estere Seinkmane

Abstract Although costly to maintain, protein homeostasis is indispensable for normal cellular function and long-term health. In mammalian cells and tissues, daily variation in global protein synthesis has been observed, but its utility and consequences for proteome integrity are not fully understood. Using several different pulse-labelling strategies, here we gain direct insight into the relationship between protein synthesis and abundance proteome-wide.

Time heals all wounds Disrupting circadian rhythm, the 24-hour cycle corresponding to light and darkness, is associated with disease and aging. Here, Hoyle et al. discovered a role for circadian control in wound healing. Skin wounds in mice wounded during the circadian rest period healed less quickly than those wounded during the active period. The authors uncovered a circadian regulation of actin, a cytoskeletal protein involved in cell migration, in fibroblasts in the wound-healing response.