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Esthel Penard on Muck Rack

Esthel Penard

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Articles

Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

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By Roberto Notario Manzano, Thibault Chaze, Eric Rubinstein, Esthel Penard
| eLife
eLife assessment Notario Manzano et al. offer a valuable first analysis of proteins within tunneling nanotubes (TNTs), membranous bridges connecting cells. This work distinguishes TNTs from extracellular vesicles, but further experimental and analytical tools are needed to refine the TNT proteome. Solid data supports a role for tetraspanins CD9 and CD81 in TNT function. The proposed model for CD9 and CD81 is over-interpreted and requires additional evidence for stronger support.
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