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Esther Barth on Muck Rack

Esther Barth

As seen in: Science Magazine, BioRxiv
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Articles

Pathogenesis of mtDNA point mutation m.10191T>C affecting complex I function is a multifactorial process leading to metabolic remodeling of mitochondria | bioRxiv

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By Alfredo Cabrera-Orefice, Marta Zaninello, Esther Barth, Zeinab Alsadat Ahmadi
| BioRxiv
Abstract Inherited mitochondrial disorders are of multiple genetic origins and may lead to a broad range of frequently severe disease phenotypes. Yet, the correlation between molecular causes and clinical presentations is poorly understood. To address this conundrum, we thoroughly investigated the consequences of the well-known pathogenic mitochondrial DNA mutation m.10191T>C.
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